Daniel Jones, Giants: Injured his neck and is questionable for Week 13. Mike Glennon will fill in if necessary.
D’Andre Swift, Lions: Suffered an injury to his AC joint and is expected to miss multiple weeks. Jamaal Williams will be the primary back while Swift is out.
Dalvin Cook, Vikings: Left Week 12 with a dislocated shoulder and is expected to miss 2-3 weeks. Alexander Mattison is the new workhorse in Minnesota.
Darrell Henderson, Rams: Suffered a quad strain and is questionable for Week 13. Sony Michel would carry the load in his absence.
Deebo Samuel, 49ers: Suffered a groin injury and is expected to miss 1 to 2 weeks. Jauan Jennings should benefit the most from his absence.
Darren Waller, Raiders: Suffered a knee strain and will miss 1 or 2 games. Foster Moreau will fill in.
Pat Freiermuth, Steelers: Suffered a concussion, but is expected to play in Week 13.
Dan Arnold, Jaguars: Left Week 12 with a MCL sprain and is expected to miss 4-6 weeks. James O'Shaughnessy is next on deck.