Justin Herbert, Chargers: Herbert jammed his throwing hand in Week 3, but ended up not missing any plays and is fully expected to be fine for Week 4.
James White, Patriots: White hurt his hip severely enough that the entire season could be in jeopardy. Brandon Bolden should become the primary pass-catching back for now.
Giovani Bernard, Bucs: Hurt his MCL in the final minutes of the Week 3 loss in Los Angeles. Week 4 is currently uncertain; Leonard Fournette gets a bump if Bernard is out.
Darrell Henderson, Rams: Missed Week 3 due to bruised ribs, leaving Sony Michel to carry the load. May return in Week 4 but would likely be limited even if he does.
Christian McCaffrey, Panthers: Left Week 3 with a hamstring injury and is expected to miss a few weeks. Chuba Hubbard becomes the workhorse with McCaffrey not around.
AJ Brown, Titans: Brown tweaked his hamstring in what could turn into a 2-4 week injury. Chester Rogers and/or Josh Reynold could benefit in Brown’s absence.
Julio Jones, Titans: Missed much of the second half of Week 3 in what was later determined to be a leg injury, something Jones is no stranger to. With AJ Brown also out, the Titans may look to sign someone off the street.
Tee Higgins, Bengals: Higgins missed Week 3 with a shoulder injury and isn’t practicing yet, which doesn’t make his playing in a short Week 4 (Thursday night) look good. Tyler Boyd becomes a lot more attractive in Higgins’ absence.
JuJu Smith-Schuster, Steelers: Left Week 3 with rib bruising, in which X-Rays were negative. Status for Week 4 is up in the air; Chase Claypool would be the biggest beneficiary if Smith-Schuster misses time.
Sterling Shepard/Darius Slayton, Giants: Both left Week 3 with a hamstring injuries. Status for Week 4 is unknown. Kadarius Toney will be forced into a bigger workload if one or both miss the game.
KJ Hamler, Broncos: Hamler tore his ACL and is lost for the season. Broncos will look to pick up the slack with Tim Patrick getting a large boost.
Elijah Moore, Jets: Left Week 3 with a concussion; status for Week 4 is unknown.
Tyler Croft, Jets: Croft left Week 3 with a chest injury, and his status is currently unknown. Ryan Griffin would be the target benefit if Croft remains out.